Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 16/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2701364 | 0.95 | REN (0.39) | ALDH1A1RENTSHR | |
| SCHEMBL4630110 | 0.89 | REN (0.36) | REN | |
| SCHEMBL28874795 | 0.82 | PRCP (0.41) | ALDH1A1TSHR | |
| SCHEMBL4630457 | 0.81 | PRCP (0.44) | ALDH1A1TSHR | |
| SCHEMBL4630350 | 0.80 | PRCP (0.39) | ALDH1A1 | |
| SCHEMBL5543593 | 0.79 | — | — | |
| SCHEMBL5537138 | 0.78 | — | — | |
| SCHEMBL4630213 | 0.76 | HSD17B10 (0.35) | — | |
| SCHEMBL4630220 | 0.74 | SLC6A1 (0.31) | — | |
| SCHEMBL27468849 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919907-A2 | HETEROCYCLIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007026959-A2 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZ0 [B] THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-03-08 | — | — | WO | disclosed |