Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.67 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | GRK2 | P25098 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630900 | 0.85 | NOTUM (0.48) | NOTUMPORCNALDH1A1ROCK2ROCK1 | |
| SCHEMBL6716890 | 0.83 | NOTUM (0.72) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL4630981 | 0.83 | NOTUM (0.46) | NOTUMPORCNADRA2CNAMPTROCK2 | |
| SCHEMBL4518077 | 0.82 | PORCN (0.64) | PORCNALDH1A1LMNAROCK2ROCK1 | |
| SCHEMBL4630930 | 0.81 | PORCN (0.46) | NOTUMPORCNALDH1A1LMNAROCK2 | |
| SCHEMBL4630248 | 0.81 | PORCN (0.46) | NOTUMPORCNALDH1A1LMNAROCK2 | |
| Hydrochloric Acid SCHEMBL4522424 | 0.81 | PORCN (0.63) | PORCNALDH1A1LMNAROCK2ROCK1 | |
| SCHEMBL20941790 | 0.77 | NOTUM (0.57) | NOTUMALDH1A1LMNAPKMMEN1 | |
| SCHEMBL6715566 | 0.77 | NOTUM (0.60) | NOTUMALDH1A1LMNAMEN1KMT2A | |
| Trifluoroacetic Acid SCHEMBL4535893 | 0.75 | PORCN (0.57) | PORCNALDH1A1LMNAROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |