Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | GRK2 | P25098 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631344 | 0.81 | NOTUM (0.67) | PORCNROCK2ROCK1NOTUMGRK2 | |
| SCHEMBL4630930 | 0.81 | PORCN (0.46) | PORCNROCK2ROCK1NOTUMLMNA | |
| SCHEMBL4630900 | 0.79 | NOTUM (0.48) | PORCNROCK2ROCK1NOTUMALDH1A1 | |
| SCHEMBL4518077 | 0.79 | PORCN (0.64) | PORCNROCK2ROCK1GRK2LMNA | |
| Hydrochloric Acid SCHEMBL4522424 | 0.78 | PORCN (0.63) | PORCNROCK2ROCK1GRK2LMNA | |
| SCHEMBL4630981 | 0.77 | NOTUM (0.46) | PORCNROCK2ROCK1NOTUM | |
| SCHEMBL4520975 | 0.73 | ROCK2 (0.53) | ROCK2ROCK1LMNAALDH1A1MEN1 | |
| Trifluoroacetic Acid SCHEMBL4535893 | 0.72 | PORCN (0.57) | PORCNROCK2ROCK1GRK2LMNA | |
| SCHEMBL11178746 | 0.72 | AAK1 (0.55) | ROCK2ROCK1ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4524018 | 0.71 | LMNA (0.55) | ROCK2ROCK1NOTUMLMNANPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922306-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | Astellas Pharma Inc. (JP) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007026920-A2 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2007-03-08 | — | — | WO | disclosed |