Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PORCN | Q9H237 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.49 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.49 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4518077 | 0.92 | PORCN (0.64) | PORCNMGLLALDH1A1RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL4522424 | 0.91 | PORCN (0.63) | PORCNMGLLALDH1A1RAB9AMEN1 | |
| SCHEMBL1561387 | 0.77 | MAPT (0.70) | MGLLALDH1A1RAB9AMEN1LMNA | |
| SCHEMBL4631344 | 0.75 | NOTUM (0.67) | PORCNALDH1A1MEN1LMNAMAPT | |
| Hydrochloric Acid SCHEMBL11858514 | 0.75 | MAPT (0.68) | MGLLALDH1A1RAB9AMEN1LMNA | |
| SCHEMBL14605463 | 0.75 | ROCK2 (0.67) | PORCNMGLLALDH1A1LMNAMAPT | |
| SCHEMBL403203 | 0.75 | RAB9A (0.56) | PORCNMGLLALDH1A1RAB9AMEN1 | |
| Trifluoroacetic Acid SCHEMBL29958833 | 0.74 | BCHE (0.45) | MEN1LMNAKMT2AROCK2GRK2 | |
| Hydrochloric Acid SCHEMBL15778253 | 0.74 | ROCK2 (0.49) | PORCNROCK2ROCK1HDAC1HDAC6 | |
| SCHEMBL4630900 | 0.73 | NOTUM (0.48) | PORCNALDH1A1ROCK2ROCK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211919-B2 | Amide derivatives as rock inhibitors | ASTELLAS PHARMA INC. (JP) | 2012-07-03 | — | — | US | disclosed |
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ASTELLAS PHARMA INC. (JP) | 2009-04-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105231-A1 | AMIDE DERIVATIVES AS ROCK INHIBITORS | ROCK1, ROCK2, RHOA | PORCN 4455/4885MGLL 2662/4885ALDH1A1 3985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.