Dorsomorphin

Dorsomorphin

SCHEMBL463155

c1cc(-c2cnn3cc(-c4ccc(OCCN5CCCCC5)cc4)cnc23)ccn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 11/20 1.00
FLT1 P17948 10/20 1.00
BMP4 P12644 8/20 1.00
PRKAB2 O43741 6/20 1.00
PRKAG1 P54619 6/20 1.00
PRKAA2 P54646 6/20 1.00
PRKAA1 Q13131 6/20 1.00
PRKAG3 Q9UGI9 6/20 1.00
PRKAG2 Q9UGJ0 6/20 1.00
PRKAB1 Q9Y478 6/20 1.00
ACVR1 Q04771 5/20 1.00
LCK P06239 4/20 1.00
SRC P12931 4/20 1.00
EPHA2 P29317 4/20 1.00
RPS6KA1 Q15418 4/20 1.00
MKNK1 Q9BUB5 4/20 1.00
BMPR1B O00238 2/20 1.00
BMPR1A P36894 2/20 1.00
ACVR1B P36896 2/20 1.00
ACVRL1 P37023 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dorsomorphin SCHEMBL2119244 0.99 KDR (0.98) KDRFLT1BMP4PRKAB2PRKAG1
Dorsomorphin SCHEMBL17845800 0.99 KDR (0.98) KDRFLT1BMP4PRKAB2PRKAG1
Dorsomorphin SCHEMBL26968137 0.97 KDR (0.94) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL2059672 0.91 BMP4 (1.00) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL11953875 0.91 KDR (0.83) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL2059673 0.90 PRKAB1 (1.00) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL31087251 0.90 KDR (0.81) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL13126023 0.90 FLT1 (0.81) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL13126025 0.90 KDR (0.81) KDRFLT1BMP4PRKAB2PRKAG1
SCHEMBL13126029 0.90 FLT1 (0.81) KDRFLT1BMP4PRKAB2PRKAG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2480 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4747363-A1 NEURAL DIFFERENTIATION FROM PLURIPOTENT CELLS Treefrog Therapeutics (FR) 2026-05-27 EP claimed
EP-3594323-B1 METHODS AND COMPOSITIONS FOR GENERATING PANCREATIC PROGENITORS AND FUNCTIONAL BETA CELLS FROM HPSCS UNIV HEALTH NETWORK (CA) 2026-05-27 EP claimed
CN-122038285-A Kit and method for constructing human bone organ by using pluripotent stem cells 广东医科大学附属医院 2026-05-15 CN claimed
CN-121109298-B Serum-free induction medium and induction method for promoting differentiation of mesenchymal stem cells into dermal papilla cells 成都云测医学生物技术有限公司 2026-05-15 CN claimed
CN-122038284-A Method for inducing differentiation of anterior foregut endoderm cells to form lung progenitor cells and application thereof 广州国家实验室 2026-05-15 CN claimed
CN-122038274-A Method for inducing differentiation and maturation of alveolar organoids and application thereof 广州国家实验室 2026-05-15 CN claimed
US-12624339-B2 Brain organoid containing optic vesicles generated based on H9 induction and eye-brain fusion culture method TIANJIN UNIVERSITY (CN) 2026-05-12 US claimed
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
EP-4714459-A1 COMPOSITION FOR PREVENTING OR TREATING SALIVARY GLAND DISEASES, COMPRISING EPITHELIAL PROGENITOR CELLS OR STEM CELLS IN MINOR SALIVARY GLAND DUCT UIF (University Industry Foundation), Yonsei University (KR) 2026-03-25 EP claimed
US-20260076997-A1 CELL IMPLANT INCLUDING BIODEGRADABLE POROUS MICROWELL WITH STEM CELL-DERIVED INSULIN-SECRETING CELL AGGREGATE SUPPORTED THEREIN, AND USE THEREOF POSTECH RES & BUSINESS DEV FOUND (KR) 2026-03-19 US claimed
WO-2020235944-A1 METHOD FOR PREPARING INTESTINAL ORGANOID AND USE THEREOF 연세대학교산학협력단 (KR) 2020-11-26 WO claimed
WO-2020145708-A1 COMPOSITION AND KIT FOR DIFFERENTIATION OF STEM CELLS INTO NEURAL CREST STEM CELLS, INCLUDING INHIBITOR OF TGF-BETA I RECEPTOR AND BMP INHIBITOR, AND METHOD USING SAME 차의과학대학교 산학협력단 2020-07-16 WO claimed
EP-3613848-A1 METHOD FOR PRODUCING DOPAMINERGIC NEURONS National University Corporation Nagoya University (JP) 2020-02-26 EP claimed
CN-110582564-A derivation of liver organoids from human pluripotent stem cells 新加坡科技研究局 2019-12-17 CN claimed
US-20190216781-A1 METHODS FOR TREATING HETEROTOPIC OSSIFICATION Clementia Pharmaceuticals Inc. (CA) 2019-07-18 US claimed
EP-3468554-A1 METHODS FOR TREATING HETEROTOPIC OSSIFICATION Clementia Pharmaceuticals Inc. (CA) 2019-04-17 EP claimed
US-20180362650-A1 PD-1 SIGNAL INHIBITOR COMBINATION THERAPY KYOTO UNIVERSITY (JP) 2018-12-20 US claimed
EP-3388084-A1 PD-1 SIGNAL INHIBITOR COMBINATION THERAPY Kyoto University (JP) 2018-10-17 EP claimed
WO-2017210792-A1 METHODS FOR TREATING HETEROTOPIC OSSIFICATION Clementia Pharmaceuticals Inc. (CA) 2017-12-14 WO claimed
US-20120142093-A1 METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO NEURAL PRECURSOR CELLS KYOTO UNIVERSITY (JP) 2012-06-07 US claimed