Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPFFR1 | Q9GZQ6 | 4/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631201 | 0.84 | BCHE (0.52) | BCHEACHECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL4630841 | 0.83 | NPFFR1 (0.51) | ACHECYP3A4CYP2D6NPFFR1NPFFR2 | |
| SCHEMBL4631784 | 0.82 | OPRM1 (0.48) | BCHEACHECYP2D6KMT2AL3MBTL1 | |
| SCHEMBL7749157 | 0.81 | CYP3A4 (0.41) | BCHEACHECYP3A4CYP2D6CYP2C9 | |
| SCHEMBL7749154 | 0.78 | OPRM1 (0.41) | CYP3A4CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL2206046 | 0.77 | SIGMAR1 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL10500225 | 0.76 | CYP2D6 (0.63) | CYP3A4CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL4864670 | 0.76 | L3MBTL1 (0.77) | KMT2AL3MBTL1LMNAALDH1A1MEN1 | |
| SCHEMBL8136600 | 0.75 | CYP2D6 (0.54) | CYP3A4CYP2D6CYP2C9CYP2C19KMT2A | |
| SCHEMBL4631255 | 0.75 | POLB (0.47) | CYP3A4CYP2D6CYP2C9CYP2C19NPFFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101230008-A | Substituted heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2008-07-30 | — | — | CN | disclosed |
| EP-1923391-A1 | Substituted heterocyclic compounds, method for preparing same and pharmaceutical compositions containing them. | sanofi-aventis (FR) | 2008-05-21 | — | — | EP | disclosed |
| CN-1295221-C | Substituted heterocyclic compounds | SANOFI AVENTIS (FR) | 2007-01-17 | — | — | CN | disclosed |
| CN-1293063-C | Substituted heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2007-01-03 | — | — | CN | disclosed |
| CN-1821241-A | Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing same | SANOFI SA (FR) | 2006-08-23 | — | — | CN | disclosed |
| EP-1688416-A1 | Substituted heterocyclic compounds, their process of preparation and pharmaceutical compositions containing them | Sanofi-Aventis (FR) | 2006-08-09 | — | — | EP | disclosed |
| CN-1636983-A | Substituted heterocyclic compounds | SANOFI AVENTIS (FR) | 2005-07-13 | — | — | CN | disclosed |
| EP-1156049-B1 | Substituted heterocyclic compounds, their process of preparation and pharmaceutical compositions containing them | SANOFI AVENTIS (FR) | 2005-06-01 | — | — | EP | disclosed |
| CN-1202093-C | Substituted heterocyclic compounds | SANOFI AVENTIS (FR) | 2005-05-18 | — | — | CN | disclosed |
| CN-1179954-C | Substituted heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | ��ŵ�Ѻϳ�ʵ���� | 2004-12-15 | — | — | CN | disclosed |
| CN-1321634-A | Substd heterocyclic compounds preparing method thereof and pharmaceutical composition contg. them | SANOFI SYNTHESIZING LAB (FR) | 2001-11-14 | — | — | CN | disclosed |
| US-6242637-B1 | USED IN TREATMENT INVOLVING THE TACHYKININ SYSTEM, SUCH AS PAIN, ALLERGY AND INFLAMMATION, CIRCULATORY, GASTROINTESTINAL, NEUROLOGICAL, AND NEUROPSYCHIATRIC DISORDERS | SANOFI-SYNTHELABO (FR) | 2001-06-05 | — | — | US | disclosed |
| US-6011154-A | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 2000-01-04 | — | — | US | disclosed |
| US-5977359-A | Substituted heterocyclic compounds, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 1999-11-02 | — | — | US | disclosed |
| US-5869663-A | INTERMEDIATES FOR NEUROKININ RECEPTOR ANTAGONISTS | SANOFI (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5780466-A | DISORDERS ASSOCIATED WITH EXCESS TACHYKININS AND ALL NEUROKININ-DEPENDENT DISORDERS; ANALGESICS; RESPIRATORY, GASTROINTESTINAL, UROGENTIAL, IMMUNE, CARDIOVASCULAR AND CNS DISORDERS | SANOFI (FR) | 1998-07-14 | — | — | US | disclosed |
| CN-1172483-A | Substituted heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-02-04 | — | — | CN | disclosed |
| EP-0807111-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1997-11-19 | — | — | EP | disclosed |
| US-5641777-A | NEUROKININ RECEPTOR ANTAGONIST | SANOFI (FR) | 1997-06-24 | — | — | US | disclosed |
| WO-1996023787-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI (FR) | 1996-08-08 | — | — | WO | disclosed |