Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.39 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633313 | 0.92 | KMT2A (0.49) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL29447926 | 0.90 | KMT2A (0.47) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL25253595 | 0.90 | KMT2A (0.47) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL25298464 | 0.90 | ALDH1A1 (0.51) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL29809012 | 0.90 | ALDH1A1 (0.51) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL22115119 | 0.81 | LMNA (0.66) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL3106666 | 0.77 | SMN1; SMN2 (0.59) | HTTALDH1A1LMNAL3MBTL1TSHR | |
| SCHEMBL865237 | 0.77 | LMNA (0.65) | ALDH1A1LMNAHCAR3TSHRCYP3A4 | |
| SCHEMBL11350169 | 0.77 | KMT2A (0.68) | KMT2AHTTALDH1A1LMNAMEN1 | |
| SCHEMBL5914014 | 0.76 | TSHR (0.68) | KMT2AHTTALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2008017466-A1 | PHARMACEUTICALLY ACTIVE TETRAHYDROISOQUINOLINE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2008-02-14 | — | — | WO | disclosed |
| WO-2007023135-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2007-03-01 | — | — | WO | disclosed |