Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.54 |
| ▸ | GUSB | P08236 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633353 | 0.82 | NCF1 (0.57) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL15101603 | 0.80 | LMNA (0.73) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL31673809 | 0.80 | LMNA (0.73) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL4742006 | 0.77 | TSHR (0.67) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL4632754 | 0.77 | TSHR (0.67) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL4633311 | 0.77 | TSHR (0.67) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL4632598 | 0.77 | HTR7 (0.50) | TSHRHTTNPC1 | |
| SCHEMBL4825210 | 0.75 | HTR7 (0.58) | TSHRHTTNPC1KDM4E | |
| SCHEMBL13692602 | 0.75 | NPC1 (0.97) | TSHRHTTNPC1GUSBMAPT | |
| SCHEMBL6333177 | 0.73 | TSHR (0.63) | TSHRHTTNPC1GUSBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1603884-A4 | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. | ENCYSIVE PHARMACEUTICALS INC (US) | 2008-05-28 | — | — | EP | disclosed |
| EP-1603884-A2 | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004078114-A2 | PYRIDINE, PYRIMIDINE, QUINOLINE, QUINAZOLINE, AND NAPHTHALENE UROTENSIN-II RECEPTOR ANTAGONISTS. | ENCYSIVE PHARMACEUTICALS INC. (US) | 2004-09-16 | — | — | WO | disclosed |