Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3178029 | 0.99 | GAA (0.60) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL3167721 | 0.91 | GAA (0.57) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL3182873 | 0.91 | GAA (0.53) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| Hydrochloric Acid SCHEMBL3184875 | 0.91 | GAA (0.56) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| Hydrochloric Acid SCHEMBL3183536 | 0.90 | GAA (0.52) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL21600228 | 0.84 | GAA (0.73) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL22865971 | 0.84 | GAA (0.73) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL21600566 | 0.84 | GAA (0.73) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL16445988 | 0.84 | GAA (0.73) | GAAOPRM1OPRD1OPRK1GRIN2D | |
| SCHEMBL18878754 | 0.84 | GAA (0.73) | GAAOPRM1OPRD1OPRK1GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554282-B1 | MORPHINAN DERIVATIVES SUBSTITUTED IN POSITION 14 AND QUATERNARY AMMONIUM SALTS THEREOF, METHOD FOR PRODUCTION AND USE THEREOF | ALCASYNN PHARMACEUTICALS GMBH (AT) | 2008-05-28 | — | — | EP | claimed |
| US-20050182258-A1 | Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof | ALCASYNN PHARMACEUTICALS GMBH (AT) | 2005-08-18 | — | — | US | claimed |
| EP-1554282-B1 | MORPHINAN DERIVATIVES SUBSTITUTED IN POSITION 14 AND QUATERNARY AMMONIUM SALTS THEREOF, METHOD FOR PRODUCTION AND USE THEREOF | ALCASYNN PHARMACEUTICALS GMBH (AT) | 2008-05-28 | — | — | EP | disclosed |
| US-20080064712-A1 | Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof | ALCASYNN PHARMACEUTICALS GMBH | 2008-03-13 | — | — | US | disclosed |
| US-20050182258-A1 | Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof | ALCASYNN PHARMACEUTICALS GMBH (AT) | 2005-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182258-A1 | Morphinan derivatives the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof | OPRM1, OPRD1, OPRK1 | GAA 2197/4885OPRM1 1/4885OPRD1 2/4885 |
| US-20080064712-A1 | Morphinan derivatives, the quaternary ammonium salts thereof substituted in position 14, method for production and use thereof | OPRM1, OPRD1, OPRK1 | GAA 2204/4885OPRM1 1/4885OPRD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.