Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633594 | 0.89 | FGFR1 (0.48) | HDAC6CDK2CCNA2CCNA1MAP4K4 | |
| SCHEMBL4631794 | 0.88 | AURKA (0.46) | CDK2CCNA2CCNA1MAPTKDM4E | |
| SCHEMBL4631749 | 0.87 | CDK2 (0.49) | HDAC6CDK2CCNA2CCNA1MAP4K4 | |
| SCHEMBL4633297 | 0.87 | HDAC6 (0.48) | HDAC6KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL4632622 | 0.86 | HDAC6 (0.53) | HDAC6CDK2CCNA2CCNA1MAPT | |
| SCHEMBL4632536 | 0.85 | FLT3 (0.51) | HDAC6CDK2MAPTKDM4EALDH1A1 | |
| SCHEMBL4631888 | 0.85 | NPC1 (0.42) | HDAC6KDM4EALDH1A1KMT2ANPC1 | |
| SCHEMBL4632682 | 0.85 | HDAC6 (0.38) | HDAC6FLT3CDK7FGFR1FGFR2 | |
| SCHEMBL4632532 | 0.83 | P2RY14 (0.44) | HDAC6CDK2CCNA2CCNA1MAPT | |
| SCHEMBL4632670 | 0.83 | FLT3 (0.51) | HDAC6CDK2CDC7DAPK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |