Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 3/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4632670 | 0.86 | FLT3 (0.51) | HDAC6FLT3HDAC3FGFR1FGFR2 | |
| SCHEMBL4633594 | 0.86 | FGFR1 (0.48) | HDAC6FLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL4632650 | 0.85 | HDAC6 (0.42) | HDAC6FLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL4633592 | 0.84 | HDAC6 (0.40) | HDAC6FLT3HDAC3NCOR2FGFR1 | |
| SCHEMBL4631749 | 0.84 | CDK2 (0.49) | HDAC6FGFR1FGFR2FGFR3CDK7 | |
| SCHEMBL4632616 | 0.84 | KDR (0.46) | HDAC6FLT3HDAC1KITTNIK | |
| SCHEMBL4633207 | 0.84 | HDAC6 (0.45) | HDAC6FLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL4633324 | 0.84 | ABL1 (0.47) | HDAC6FLT3HDAC1KIT | |
| SCHEMBL4632622 | 0.83 | HDAC6 (0.53) | HDAC6FLT3CDK7 | |
| SCHEMBL4631770 | 0.83 | ABL1 (0.48) | HDAC6FLT3HDAC1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |