Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 5/20 | 0.51 |
| ▸ | KIT | P10721 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633601 | 0.90 | FLT3 (0.42) | FLT3KITLRRK2HDAC3HDAC1 | |
| SCHEMBL4633207 | 0.89 | HDAC6 (0.45) | FLT3KITHDAC1FGFR1FGFR2 | |
| SCHEMBL2432388 | 0.87 | FLT3 (0.47) | FLT3KITLRRK2FOXO1HDAC3 | |
| SCHEMBL4632682 | 0.86 | HDAC6 (0.38) | FLT3KITHDAC3HDAC1FGFR1 | |
| SCHEMBL4632536 | 0.86 | FLT3 (0.51) | FLT3KITFGFR1FGFR2HDAC6 | |
| SCHEMBL3102304 | 0.85 | FLT3 (0.50) | FLT3KITLRRK2FOXO1HDAC3 | |
| SCHEMBL4633594 | 0.84 | FGFR1 (0.48) | FLT3FGFR1FGFR2HDAC6CLK2 | |
| SCHEMBL4632622 | 0.83 | HDAC6 (0.53) | FLT3HDAC6CDK2CDK7 | |
| SCHEMBL4632650 | 0.83 | HDAC6 (0.42) | FLT3FGFR1FGFR2HDAC6CLK2 | |
| SCHEMBL4631888 | 0.82 | NPC1 (0.42) | LRRK2FGFR1FGFR2HDAC6FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |