Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633322 | 0.88 | SMN1; SMN2 (0.53) | HDAC6CCNA2CDK2CCNA1CDK7 | |
| SCHEMBL4633594 | 0.87 | FGFR1 (0.48) | HDAC6CCNA2CDK2CCNA1AURKA | |
| SCHEMBL4633297 | 0.87 | HDAC6 (0.48) | HDAC6SMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL4632650 | 0.86 | HDAC6 (0.42) | HDAC6CCNA2CDK2CCNA1CSNK2A2 | |
| SCHEMBL4631888 | 0.86 | NPC1 (0.42) | HDAC6ADORA3MEN1KMT2ANPC1 | |
| SCHEMBL4632536 | 0.86 | FLT3 (0.51) | HDAC6CDK2CDK7FLT3TP53 | |
| SCHEMBL4632621 | 0.85 | HDAC6 (0.53) | HDAC6CCNA2CDK2CCNA1AURKA | |
| SCHEMBL4631749 | 0.85 | CDK2 (0.49) | HDAC6CCNA2CDK2CCNA1CSNK2A1 | |
| SCHEMBL4632682 | 0.83 | HDAC6 (0.38) | HDAC6CDK7FLT3 | |
| SCHEMBL4632670 | 0.83 | FLT3 (0.51) | HDAC6CDK2CDK7FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1711177-B1 | 1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-05-28 | — | — | EP | claimed |