Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116356 | 0.82 | HSD17B10 (0.46) | SMN1; SMN2HSD17B10L3MBTL1CYP11B2LMNA | |
| SCHEMBL46303 | 0.77 | HSD17B10 (0.46) | SMN1; SMN2MAPTHSD17B10L3MBTL1CYP11B1 | |
| SCHEMBL24542664 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTHSD17B10ATML3MBTL1 | |
| SCHEMBL29682836 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2MAPTHSD17B10ATML3MBTL1 | |
| SCHEMBL29682805 | 0.74 | ATM (0.41) | SMN1; SMN2MAPTHSD17B10ATML3MBTL1 | |
| SCHEMBL24542645 | 0.74 | ATM (0.41) | SMN1; SMN2MAPTHSD17B10ATML3MBTL1 | |
| SCHEMBL31739850 | 0.72 | POLB (0.37) | SMN1; SMN2MAPTMAP4K1HSD17B10ATM | |
| SCHEMBL12457541 | 0.72 | L3MBTL1 (0.46) | SMN1; SMN2HSD17B10L3MBTL1PIP4K2AHTT | |
| SCHEMBL24441089 | 0.70 | CYP11B1 (0.35) | SMN1; SMN2CYP11B1CYP11B2TDP1HTT | |
| SCHEMBL7806296 | 0.69 | MAPT (0.54) | SMN1; SMN2MAPTATMHTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151436-A2 | NOVEL COMPOUNDS, METHOD FOR USE THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM | EUROSCREEN S.A. (BE) | 2011-12-08 | — | — | WO | disclosed |