Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | SENP5 | Q96HI0 | 13/20 | 0.48 |
| ▸ | SENP2 | Q9HC62 | 13/20 | 0.48 |
| ▸ | SENP1 | Q9P0U3 | 13/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4605877 | 0.90 | SENP5 (0.48) | SENP5SENP2SENP1MRGPRX4USP2 | |
| SCHEMBL4633007 | 0.87 | KMT2A (0.55) | KDM4EALDH1A1SENP5SENP2SENP1 | |
| SCHEMBL4634443 | 0.86 | SENP2 (0.62) | KDM4EALDH1A1EDNRASENP5SENP2 | |
| SCHEMBL484955 | 0.85 | CXCR2 (0.65) | SENP5SENP2SENP1USP2CXCR2 | |
| SCHEMBL4634951 | 0.85 | KDM4E (0.67) | KDM4EALDH1A1EDNRASENP5SENP2 | |
| SCHEMBL4632927 | 0.84 | SENP2 (0.59) | KDM4EALDH1A1EDNRASENP5SENP2 | |
| Bicarbonate SCHEMBL485488 | 0.83 | SENP5 (0.45) | ALDH1A1SENP5SENP2SENP1USP2 | |
| SCHEMBL485732 | 0.83 | CXCR2 (0.52) | SENP5SENP2SENP1USP2CXCR2 | |
| SCHEMBL485760 | 0.82 | NPC1 (0.46) | ALDH1A1SENP5SENP2SENP1USP2 | |
| SCHEMBL485385 | 0.82 | SENP2 (0.46) | SENP5SENP2SENP1USP2CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |