Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | SENP5 | Q96HI0 | 9/20 | 0.44 |
| ▸ | SENP2 | Q9HC62 | 9/20 | 0.44 |
| ▸ | SENP1 | Q9P0U3 | 9/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL485488 | 0.98 | SENP5 (0.45) | NPC1RAB9AEPHX1EPHX2SENP5 | |
| SCHEMBL486273 | 0.88 | SENP5 (0.56) | NPC1RAB9ASENP5SENP2SENP1 | |
| SCHEMBL4632958 | 0.82 | KDM4E (0.51) | SENP5SENP2SENP1ALDH1A1USP2 | |
| SCHEMBL485551 | 0.82 | ALDH1A1 (0.49) | NPC1RAB9AEPHX1EPHX2MEN1 | |
| SCHEMBL485385 | 0.80 | SENP2 (0.46) | SENP5SENP2SENP1USP2 | |
| SCHEMBL4605877 | 0.80 | SENP5 (0.48) | SENP5SENP2SENP1USP2 | |
| SCHEMBL485455 | 0.80 | CXCR2 (0.49) | NPC1EPHX1EPHX2MEN1ALDH1A1 | |
| SCHEMBL484955 | 0.80 | CXCR2 (0.65) | SENP5SENP2SENP1USP2 | |
| SCHEMBL4633007 | 0.79 | KMT2A (0.55) | SENP5SENP2SENP1ALDH1A1KMT2A | |
| SCHEMBL485783 | 0.78 | MRGPRX4 (0.47) | EPHX1EPHX2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836158-B1 | FUSED BICYCLIC CARBOXAMIDE DERIVATIVES FOR USE AS CXCR2 INHIBITORS IN THE TREATMENT OF INFLAMMATION | SANOFI AVENTIS DEUTSCHLAND (DE) | 2012-02-01 | — | — | EP | claimed |