Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | MAX | P61244 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633263 | 0.75 | CTSV (0.44) | CTSVCTSLCYP19A1KMT2AMYC | |
| SCHEMBL3607727 | 0.75 | CTSV (0.48) | CTSVCTSLCYP19A1MEN1KMT2A | |
| SCHEMBL3607732 | 0.75 | CTSV (0.48) | CTSVCTSLCYP19A1MEN1KMT2A | |
| SCHEMBL3255304 | 0.75 | CTSV (0.44) | CTSVCTSLCYP19A1MEN1KMT2A | |
| SCHEMBL6019985 | 0.74 | ABCB1 (0.42) | CTSVCTSLCYP19A1MEN1KMT2A | |
| SCHEMBL31473699 | 0.73 | POLB (0.57) | CTSVCTSLMEN1KMT2AABCB1 | |
| SCHEMBL1312167 | 0.73 | POLB (0.57) | CTSVCTSLMEN1KMT2AABCB1 | |
| SCHEMBL4407305 | 0.71 | CTSV (0.42) | CTSVCTSLCYP19A1MEN1KMT2A | |
| SCHEMBL2498156 | 0.71 | KMT2A (0.66) | MEN1KMT2AGAAMAPTINPPL1 | |
| SCHEMBL1583614 | 0.71 | POLB (0.48) | CTSVCTSLCYP19A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |