Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 5/20 | 0.44 |
| ▸ | CTSL | P07711 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAX | P61244 | 1/20 | 0.38 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4407305 | 0.82 | CTSV (0.42) | CTSVCTSLMAPTAKR1C3AKR1C2 | |
| SCHEMBL3607732 | 0.80 | CTSV (0.48) | CTSVCTSLMAPTAKR1C3AKR1C2 | |
| SCHEMBL3607727 | 0.80 | CTSV (0.48) | CTSVCTSLMAPTAKR1C3AKR1C2 | |
| SCHEMBL4633259 | 0.75 | CTSV (0.43) | CTSVCTSLMAPTCYP19A1MYC | |
| SCHEMBL3255304 | 0.74 | CTSV (0.44) | CTSVCTSLMAPTAKR1C3AKR1C2 | |
| SCHEMBL29197789 | 0.73 | PIN1 (0.46) | CTSVCTSLMAPTSMN1; SMN2CYP19A1 | |
| SCHEMBL22711369 | 0.72 | THRA (0.51) | MAPTALDH1A1SMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL6019985 | 0.71 | ABCB1 (0.42) | CTSVCTSLMAPTCYP19A1PKM | |
| SCHEMBL8391099 | 0.70 | AKR1C3 (0.71) | CTSVCTSLMAPTAKR1C3AKR1C2 | |
| SCHEMBL31473699 | 0.70 | POLB (0.57) | CTSVCTSLMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |