Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.54 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL17543975 | 0.91 | TSHR (0.61) | TSHRTP53CRBNDDB1CA1 | |
| Terephthalic Acid SCHEMBL29048824 | 0.91 | CRBN (0.56) | TSHRTP53CRBNDDB1CA1 | |
| Terephthalic Acid SCHEMBL29200788 | 0.91 | CRBN (0.56) | TSHRTP53CRBNDDB1CA1 | |
| Succinimide SCHEMBL27830760 | 0.90 | BCL2L1 (0.59) | TSHRTP53CRBNDDB1CA1 | |
| Succinimide SCHEMBL28035341 | 0.87 | ALDH1A1 (0.68) | TSHRTP53CRBNDDB1CA1 | |
| Benzoic Acid SCHEMBL28099052 | 0.86 | TSHR (0.54) | TSHRTP53CRBNDDB1CA1 | |
| Benzoic Acid SCHEMBL28697460 | 0.83 | TSHR (0.56) | TSHRTP53CRBNDDB1SRD5A2 | |
| Succinimide SCHEMBL9294241 | 0.80 | SMYD3 (0.58) | CRBNSRD5A2ALDH1A1TDP2HTT | |
| Succinimide SCHEMBL6717091 | 0.79 | CRBN (0.73) | TSHRCRBNDDB1CA1CA9 | |
| Succinimide SCHEMBL6036901 | 0.79 | CRBN (0.73) | TSHRCRBNDDB1CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080128322-A1 | TRACTION COEFFICIENT REDUCING LUBRICATING OIL COMPOSITION | CHEVRON ORONITE COMPANY LLC (US) | 2008-06-05 | — | — | US | disclosed |
| EP-1927647-A1 | Traction coefficient reducing lubricating oil composition | Chevron Oronite Company LLC (US) | 2008-06-04 | — | — | EP | disclosed |