Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL29048824 | 1.00 | CRBN (0.56) | CRBNTSHRTP53DDB1MAPT | |
| Benzoic Acid SCHEMBL28697460 | 0.92 | TSHR (0.56) | CRBNTSHRTP53DDB1MAPT | |
| Terephthalic Acid SCHEMBL4633354 | 0.91 | TSHR (0.57) | CRBNTSHRTP53DDB1HTT | |
| Benzoic Acid SCHEMBL17543975 | 0.83 | TSHR (0.61) | CRBNTSHRTP53DDB1HPGD | |
| Succinimide SCHEMBL27830760 | 0.82 | BCL2L1 (0.59) | CRBNTSHRTP53DDB1CA1 | |
| Bicarbonate SCHEMBL28617859 | 0.81 | CRBN (0.77) | CRBNTSHRDDB1MAPTALDH1A1 | |
| Bicarbonate SCHEMBL28617862 | 0.81 | CRBN (0.77) | CRBNTSHRDDB1MAPTALDH1A1 | |
| Succinimide SCHEMBL28035341 | 0.79 | ALDH1A1 (0.68) | CRBNTSHRTP53DDB1MAPT | |
| SCHEMBL940361 | 0.79 | MAPT (0.62) | CRBNMAPTHTTALDH1A1TDP2 | |
| Oxalic Acid SCHEMBL30524294 | 0.79 | CRBN (0.72) | CRBNTSHRDDB1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110540511-B | Extraction and purification method of diamine salt | 上海凯赛生物技术股份有限公司 | 2024-05-03 | — | — | CN | disclosed |