SCHEMBL4633646

SCHEMBL4633646

[2H]C([2H])([2H])N(C(=O)c1cc([N+](=O)[O-])c2nc(C)[nH]c2c1)C([2H])([2H])[2H]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.36
ALDH1A1 P00352 2/20 0.36
HSP90AA1 P07900 1/20 0.35
ESR2 Q92731 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
IRAK4 Q9NWZ3 1/20 0.35
RAB9A P51151 2/20 0.34
KMT2A Q03164 2/20 0.34
HTT P42858 2/20 0.34
TSHR P16473 2/20 0.34
DHODH Q02127 2/20 0.34
POLB P06746 2/20 0.33
MGAM O43451 1/20 0.33
GAA P10253 1/20 0.33
SI P14410 1/20 0.33
MGAM2 Q2M2H8 1/20 0.33
MEN1 O00255 1/20 0.33
CTDSP1 Q9GZU7 1/20 0.33
HPGD P15428 2/20 0.33
GRIN2D O15399 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4633149 0.91 LMNA (0.43) LMNAALDH1A1HSP90AA1ESR2TDP1
SCHEMBL4633141 0.81 HSP90AA1 (0.50) LMNAALDH1A1HSP90AA1ESR2TDP1
SCHEMBL4633001 0.81 HSP90AA1 (0.38) ALDH1A1HSP90AA1ESR2TDP1RAB9A
SCHEMBL4633291 0.76 KMT2A (0.48) LMNAALDH1A1HSP90AA1RAB9AKMT2A
SCHEMBL21203057 0.72 HTT (0.41) ALDH1A1HSP90AA1ESR2TDP1RAB9A
SCHEMBL29809461 0.72 HTT (0.41) ALDH1A1HSP90AA1ESR2TDP1RAB9A
SCHEMBL1281660 0.71 SMN1; SMN2 (0.42) LMNAHTTTSHRDHODHMGAM
SCHEMBL30480768 0.70 HSP90AA1 (0.40) ALDH1A1HSP90AA1ESR2TDP1RAB9A
SCHEMBL4668543 0.70 CYP3A4 (0.41) DHODHCYP1A2CYP3A4
SCHEMBL24963453 0.69 HSP90AA1 (0.38) ALDH1A1HSP90AA1ESR2TDP1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1926714-A1 ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES Nycomed GmbH (DE) 2008-06-04 EP disclosed
WO-2007023135-A1 ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES NYCOMED GMBH (DE) 2007-03-01 WO disclosed