Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.47 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.42 |
| ▸ | GSTM2 | P28161 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GALR2 | O43603 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487097 | 0.82 | CA12 (0.46) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL4633141 | 0.82 | HSP90AA1 (0.50) | KMT2AALDH1A1MAPTLMNAHSP90AA1 | |
| SCHEMBL4633149 | 0.79 | LMNA (0.43) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL6815909 | 0.77 | KMT2A (0.59) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL24985909 | 0.77 | LMNA (0.49) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL5924443 | 0.76 | ESR1 (0.69) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL4633646 | 0.76 | LMNA (0.36) | KMT2AALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL11450932 | 0.76 | CHEK1 (0.48) | ALDH1A1SMN1; SMN2MITF | |
| SCHEMBL4632328 | 0.75 | KMT2A (0.49) | KMT2AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL2655338 | 0.75 | KMT2A (0.57) | KMT2AALDH1A1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926714-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | Nycomed GmbH (DE) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007023135-A1 | ISOTOPICALLY SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | NYCOMED GMBH (DE) | 2007-03-01 | — | — | WO | disclosed |