Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4282648 | 0.82 | ADAM17 (0.41) | TAS1R3TAS1R1ALDH1A1ANPEPADAM17 | |
| SCHEMBL4273354 | 0.82 | ADAM17 (0.47) | TAS1R3TAS1R1ANPEPADAM17MMP1 | |
| SCHEMBL1817702 | 0.78 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL4269899 | 0.77 | GRN (0.41) | TAS1R3TAS1R1NOS3NOS1NOS2 | |
| SCHEMBL4634179 | 0.75 | SMN1; SMN2 (0.39) | ALDH1A1TDP1KDM4EMAPT | |
| SCHEMBL1812174 | 0.75 | ELANE (0.45) | — | |
| SCHEMBL1810431 | 0.75 | ANPEP (0.45) | TAS1R3TAS1R1NOS3NOS1NOS2 | |
| SCHEMBL1786739 | 0.72 | BTN3A1 (0.41) | ALDH1A1HSD17B10KDM4E | |
| SCHEMBL3973573 | 0.72 | GAA (0.43) | ALDH1A1NOS3NOS1NOS2ATM | |
| SCHEMBL3973571 | 0.72 | GAA (0.43) | ALDH1A1NOS3NOS1NOS2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928475-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4'-SUBSTITUTED PRONUCLEOTIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007020193-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4 ' -SUBSTITUTED PRONUCLEOTIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |