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SCHEMBL3973573

SCHEMBL3973573

CCON[C@@H](Cc1ccccc1)C(=O)OP(=O)(Cl)Oc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ ANPEP P15144 1/20 0.40
▸ LAP3 P28838 1/20 0.40
▸ HPRT1 P00492 1/20 0.40
▸ F2 P00734 2/20 0.39
▸ PLAU P00749 2/20 0.39
▸ PLAT P00750 2/20 0.39
▸ PLG P00747 1/20 0.39
▸ ELANE P08246 2/20 0.39
▸ MMP8 P22894 1/20 0.39
▸ POLB P06746 2/20 0.39
▸ PRTN3 P24158 2/20 0.38
▸ ATM Q13315 1/20 0.38
▸ LMNA P02545 2/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ GLA P06280 1/20 0.37
▸ FPR2 P25090 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ NOS3 P29474 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3973571 1.00 GAA (0.43) GAARAB9AANPEPLAP3HPRT1
SCHEMBL1811535 0.88 GAA (0.42) GAARAB9AANPEPLAP3F2
SCHEMBL10004489 0.85 RAB9A (0.49) GAARAB9AF2PLAUELANE
SCHEMBL873273 0.83 BTN3A1 (0.41) ANPEPLAP3F2PLAUPLAT
SCHEMBL3971351 0.83 BTN3A1 (0.41) ANPEPLAP3F2PLAUPLAT
SCHEMBL1812174 0.80 ELANE (0.45) RAB9AELANEPRTN3
SCHEMBL4273354 0.78 ADAM17 (0.47) ANPEP
SCHEMBL857081 0.76 ELANE (0.48) RAB9AF2PLAUPLATELANE
SCHEMBL4282648 0.76 ADAM17 (0.41) ANPEPALDH1A1TSHR
SCHEMBL5017006 0.75 FPR2 (0.51) MMP8POLBFPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1928475-B1 ANTIVIRAL PHOSPHORAMIDATES OF 4'-C-AZIDO-SUBSTITUTED PRONUCLEOTIDES RIBOSCIENCE LLC (US) 2018-05-23 — — EP disclosed
US-7608599-B2 Antiviral phosphoramidates ROCHE PALO ALTO LLC (US) 2009-10-27 — — US disclosed
WO-2009052050-A1 DIOXOLANE THYMINE PHOSPHORAMIDATES AS ANTI-HIV AGENTS PHARMASSET, INC. (US) 2009-04-23 — — WO disclosed
US-20090099136-A1 DIOXOLANE THYMINE PHOSPHORAMIDATES AS ANTI-HIV AGENTS PHARMASSET, INC. (US) 2009-04-16 — — US disclosed
EP-1928475-A2 ANTIVIRAL PHOSPHORAMIDATES OF 4'-SUBSTITUTED PRONUCLEOTIDES F.HOFFMANN-LA ROCHE AG (CH) 2008-06-11 — — EP disclosed
US-20070042988-A1 Antiviral phosphoramidates ROCHE PALO ALTO LLC 2007-02-22 — — US disclosed
WO-2007020193-A2 ANTIVIRAL PHOSPHORAMIDATES OF 4 ' -SUBSTITUTED PRONUCLEOTIDES F. HOFFMANN-LA ROCHE AG (CH) 2007-02-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042988-A1 Antiviral phosphoramidates RPP30, RNASE1, ADORA2B GAA 1564/4885RAB9A 165/4885ANPEP 1515/4885
US-20090099136-A1 DIOXOLANE THYMINE PHOSPHORAMIDATES AS ANTI-HIV AGENTS TYMP, DTYMK, TYMS GAA 723/4885RAB9A 2759/4885ANPEP 674/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.