Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 1/20 | 0.56 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 2/20 | 0.45 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.44 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.44 |
| ▸ | BAD | Q92934 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 3/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633866 | 0.88 | CXCR2 (0.67) | CXCR2PTPN2PTPN1MAPTALDH1A1 | |
| SCHEMBL4633951 | 0.85 | KDM4E (0.53) | PTPN2PTPN1ALDH1A1PRSS12EDNRA | |
| SCHEMBL4633874 | 0.85 | ALDH1A1 (0.56) | CXCR2MAPTALDH1A1MMP3RXFP1 | |
| SCHEMBL4635058 | 0.85 | CXCR2 (0.58) | CXCR2PTPN2PTPN1MAPTALDH1A1 | |
| SCHEMBL4633991 | 0.84 | CXCR2 (0.62) | CXCR2PTPN2PTPN1MAPTALDH1A1 | |
| SCHEMBL6652136 | 0.79 | PTPN2 (0.52) | CXCR2PTPN2PTPN1ALDH1A1MCL1 | |
| SCHEMBL4633952 | 0.79 | CXCR2 (0.44) | CXCR2MAPTALDH1A1MMP2MMP3 | |
| SCHEMBL4618003 | 0.78 | CXCR2 (0.56) | CXCR2MAPTALDH1A1LMNAPKM | |
| SCHEMBL4633884 | 0.78 | SENP2 (0.51) | ALDH1A1EDNRA | |
| SCHEMBL9024044 | 0.78 | CXCR2 (0.54) | CXCR2PTPN2PTPN1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |