SCHEMBL4634586

SCHEMBL4634586

Nc1c(F)cc(F)c(C(F)(F)F)c1F

nearest known ligand 0.32

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
KIF11 P52732 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9141412 0.84 KIF11 (0.31) KIF11
SCHEMBL27264874 0.82 DAO (0.32)
SCHEMBL9504384 0.81 CA12 (0.33) KIF11
SCHEMBL31423324 0.79
SCHEMBL9507060 0.77 CA1 (0.32)
SCHEMBL31422828 0.77 ALOX5AP (0.35) KIF11
SCHEMBL9503462 0.76 KIF11 (0.31) KIF11
SCHEMBL22142999 0.76
SCHEMBL17468318 0.76
SCHEMBL5814455 0.76 CA1 (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1524261-B1 Process for preparing fluorinated anilines SALTIGO GMBH (DE) 2008-06-11 EP claimed
US-7154006-B2 Preparation of fluorinated anilines BAYER AKTIENGESELLSCHAFT (DE) 2006-12-26 US claimed
US-20050101795-A1 Preparation of fluorinated anilines BAYER CHEMICALS AG 2005-05-12 US claimed
EP-1524261-A1 Process for preparing fluorinated anilines Bayer Chemicals AG (DE) 2005-04-20 EP claimed
US-5082971-A TRIFLUOROMETHYLAMINOBENZENES CONTAINING FLUORINE AND/OR CHLORINE AND THEIR PREPARATION BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 US claimed
EP-0315863-A2 Trifluoromethylamino benzenes containing fluorine, and their preparation BAYER AG (DE) 1989-05-17 EP claimed
EP-1524261-B1 Process for preparing fluorinated anilines SALTIGO GMBH (DE) 2008-06-11 EP disclosed
US-7154006-B2 Preparation of fluorinated anilines BAYER AKTIENGESELLSCHAFT (DE) 2006-12-26 US disclosed
US-20050101795-A1 Preparation of fluorinated anilines BAYER CHEMICALS AG 2005-05-12 US disclosed
EP-1524261-A1 Process for preparing fluorinated anilines Bayer Chemicals AG (DE) 2005-04-20 EP disclosed
EP-0315863-B1 Trifluoromethylamino benzenes containing fluorine, and their preparation BAYER AG (DE) 1993-11-18 EP disclosed
US-5082971-A TRIFLUOROMETHYLAMINOBENZENES CONTAINING FLUORINE AND/OR CHLORINE AND THEIR PREPARATION BAYER AKTIENGESELLSCHAFT (DE) 1992-01-21 US disclosed
EP-0315863-A2 Trifluoromethylamino benzenes containing fluorine, and their preparation BAYER AG (DE) 1989-05-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050101795-A1 Preparation of fluorinated anilines FLNA, FLNB, FLI1 KIF11 153/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.