Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4633530 | 0.88 | L3MBTL1 (0.60) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4634501 | 0.86 | MAPT (0.60) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4634465 | 0.86 | L3MBTL1 (0.50) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4634997 | 0.82 | PTPN2 (0.47) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4632923 | 0.81 | KMT2A (0.47) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4632948 | 0.80 | KMT2A (0.56) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4605523 | 0.79 | MAPT (0.43) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4633609 | 0.79 | LMNA (0.54) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4632947 | 0.79 | KMT2A (0.57) | MAPTLMNAGAANPSR1L3MBTL1 | |
| SCHEMBL4633861 | 0.78 | ALDH1A1 (0.48) | MAPTLMNAGAANPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685121-B1 | ANTIDIABETIC COMPOUNDS COMPRISING BENZOTHIOPHENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-06-11 | — | — | EP | claimed |