Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.68 |
| ▸ | THRA | P10827 | 8/20 | 0.68 |
| ▸ | PCNA | P12004 | 8/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.68 |
| ▸ | PPARG | P37231 | 2/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.68 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | GABRP | O00591 | 1/20 | 0.68 |
| ▸ | GABRD | O14764 | 1/20 | 0.68 |
| ▸ | F2 | P00734 | 1/20 | 0.68 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.68 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14509272 | 1.00 | THRB (0.68) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL17308148 | 0.90 | THRB (0.69) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL6515345 | 0.89 | THRB (0.65) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL6515348 | 0.89 | THRB (0.65) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL9301939 | 0.89 | THRB (0.65) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL24798677 | 0.88 | THRB (0.64) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL468737 | 0.88 | THRB (0.69) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL468740 | 0.88 | THRB (0.69) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL8244912 | 0.87 | THRB (0.66) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL8245248 | 0.87 | THRB (0.62) | THRBTHRAPCNALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1929030-A2 | PRODRUGS OF T3 AND T4 WITH ENHANCED BIOAVAILABILITY | Shire LLC (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070099841-A1 | Prodrugs of T3 and T4 with enhanced bioavailability | NEW RIVER PHARMACEUTICALS INC. (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070099841-A1 | Prodrugs of T3 and T4 with enhanced bioavailability | NEW RIVER PHARMACEUTICALS INC. (US) | 2007-05-03 | — | — | US | disclosed |
| US-20070099841-A1 | Prodrugs of T3 and T4 with enhanced bioavailability | NEW RIVER PHARMACEUTICALS INC. (US) | 2007-05-03 | — | — | US | disclosed |
| WO-2007030577-A2 | PRODRUGS OF T3 AND T4 WITH ENHANCED BIOAVAILABILITY | SHIRE LLC (US) | 2007-03-15 | — | — | WO | disclosed |
| WO-2007030577-A2 | PRODRUGS OF T3 AND T4 WITH ENHANCED BIOAVAILABILITY | SHIRE LLC (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099841-A1 | Prodrugs of T3 and T4 with enhanced bioavailability | THRA, THRB, SLC7A1 | THRB 2/4885THRA 1/4885PCNA 2657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.