Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501797 | 0.87 | ALDH1A1 (0.36) | MAPTALDH1A1LMNATP53POLB | |
| SCHEMBL4633775 | 0.84 | MAPT (0.38) | MAPTSMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL12502162 | 0.81 | POLB (0.33) | SMN1; SMN2ALDH1A1LMNATP53POLB | |
| SCHEMBL7113639 | 0.70 | KMT2A (0.34) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL20856173 | 0.69 | SMN1; SMN2 (0.38) | MAPTSMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL7795340 | 0.69 | SMN1; SMN2 (0.38) | MAPTSMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL4633323 | 0.68 | CETP (0.39) | MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL20162538 | 0.66 | ALDH1A1 (0.35) | MAPTSMN1; SMN2ALDH1A1LMNATP53 | |
| SCHEMBL20162506 | 0.63 | ALDH1A1 (0.38) | MAPTALDH1A1LMNA | |
| SCHEMBL472178 | 0.63 | ALDH1A1 (0.38) | MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928475-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4'-SUBSTITUTED PRONUCLEOTIDES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007020193-A2 | ANTIVIRAL PHOSPHORAMIDATES OF 4 ' -SUBSTITUTED PRONUCLEOTIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-22 | — | — | WO | disclosed |