SCHEMBL7795340

SCHEMBL7795340

CCON(c1ccccc1)[C@@H](C)C(=O)OP(=O)(O)Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.38
ALDH1A1 P00352 4/20 0.38
TP53 P04637 2/20 0.38
LMNA P02545 1/20 0.38
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
POLB P06746 2/20 0.35
MAPT P10636 1/20 0.34
TSHR P16473 2/20 0.34
KDM4E B2RXH2 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
CHRNB2 P17787 1/20 0.34
CHRNB4 P30926 1/20 0.34
CHRNA3 P32297 1/20 0.34
CHRNA4 P43681 1/20 0.34
NPC1 O15118 1/20 0.33
HTT P42858 1/20 0.33
RAB9A P51151 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
PGR P06401 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20856173 1.00 SMN1; SMN2 (0.38) SMN1; SMN2ALDH1A1TP53LMNAKMT2A
SCHEMBL20162506 0.87 ALDH1A1 (0.38) ALDH1A1LMNAMAPTTSHRKDM4E
SCHEMBL779563 0.87 SMN1; SMN2 (0.37) SMN1; SMN2ALDH1A1TP53LMNAKMT2A
SCHEMBL472178 0.87 ALDH1A1 (0.38) ALDH1A1LMNAMAPTTSHRKDM4E
SCHEMBL10004648 0.86 ALOX15 (0.39) SMN1; SMN2ALDH1A1TP53LMNAKMT2A
SCHEMBL17786771 0.86 TSHR (0.39) SMN1; SMN2ALDH1A1TP53LMNAPOLB
SCHEMBL20162521 0.86 TSHR (0.39) SMN1; SMN2ALDH1A1TP53LMNAPOLB
SCHEMBL20162538 0.85 ALDH1A1 (0.35) SMN1; SMN2ALDH1A1TP53LMNAKMT2A
SCHEMBL7028386 0.85 PTGIR (0.39)
SCHEMBL22321965 0.85 KDM4E (0.36) SMN1; SMN2ALDH1A1TP53LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163096-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NuCana plc (GB) 2025-05-22 US disclosed
US-12054510-B2 2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti-cancer compounds NuCana plc (GB) 2024-08-06 US disclosed
US-11925658-B2 Phosphoramidate derivatives of 5-fluoro-2′—deoxyuridine for use in the treatment of cancer NuCana plc (GB) 2024-03-12 US disclosed
US-20230165886-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2' - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER NuCana plc (GB) 2023-06-01 US disclosed
US-11559542-B2 Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer NuCana plc (GB) 2023-01-24 US disclosed
US-20220306675-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NuCana plc (GB) 2022-09-29 US disclosed
EP-4023299-A1 PHOSPHORAMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER Nucana PLC (GB) 2022-07-06 EP disclosed
US-11352387-B2 2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti-cancer compounds NuCana plc (GB) 2022-06-07 US disclosed
US-20220023330-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER NuCana plc (GB) 2022-01-27 US disclosed
EP-3447061-B1 PHARMACEUTICAL FORMULATION COMPRISING A PHOSPHORAMIDATE DERIVATIVE OF 5-FLUORO-2'-DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER NuCana plc (GB) 2021-11-24 EP disclosed
US-20190201432-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER CARDIFF UNIVERSITY (GB) 2019-07-04 US disclosed
EP-3224268-B1 NEW 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NuCana plc (GB) 2019-06-26 EP disclosed
EP-3031812-B1 CHEMICAL COMPOUNDS NuCana plc (GB) 2018-08-01 EP disclosed
EP-3224268-A1 NEW 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NuCana BioMed Limited (GB) 2017-10-04 EP disclosed
US-20170253629-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NUCANA BIOMED LIMITED (GB) 2017-09-07 US disclosed
US-20160166596-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER NuCana plc (GB) 2016-06-16 US disclosed
EP-3031812-A1 CHEMICAL COMPOUNDS NuCana BioMed Limited (GB) 2016-06-15 EP disclosed
WO-2016083830-A1 NEW 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS NUCANA BIOMED LIMITED (GB) 2016-06-02 WO disclosed
EP-2681227-B1 PHOSPHORAMIDATE DERIVATIVES OF 5-FLUORO-2'-DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER NUCANA BIOMED LTD (GB) 2016-02-10 EP disclosed
US-20010031745-A1 Antiviral purine derivatives UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2001-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160166596-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER SLC29A2, SLC29A1, TYMP SMN1; SMN2 2660/4885ALDH1A1 2381/4885TP53 515/4885
US-20230165886-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2' - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER SLC29A2, SLC29A1, TYMP SMN1; SMN2 2708/4885ALDH1A1 2409/4885TP53 499/4885
US-11559542-B2 Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer SLC29A2, SLC29A1, TYMP SMN1; SMN2 2657/4885ALDH1A1 2369/4885TP53 523/4885
US-20220023330-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER SLC29A2, SLC29A1, TYMP SMN1; SMN2 2660/4885ALDH1A1 2381/4885TP53 515/4885
US-20220306675-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS MTAP, ADA, ADORA2A SMN1; SMN2 2870/4885ALDH1A1 2246/4885TP53 416/4885
US-12054510-B2 2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti-cancer compounds MTAP, ADA, ADORA2A SMN1; SMN2 2913/4885ALDH1A1 2198/4885TP53 432/4885
US-20190201432-A1 PHOSPHORAMIDATE DERIVATIVES OF 5 - FLUORO - 2` - DEOXYURIDINE FOR USE IN THE TREATMENT OF CANCER SLC29A2, SLC29A1, TYMP SMN1; SMN2 2579/4885ALDH1A1 2528/4885TP53 478/4885
US-11352387-B2 2′ and/or 5′ amino-acid ester phosphoramidate 3′-deoxy adenosine derivatives as anti-cancer compounds MTAP, RNMT, ADA SMN1; SMN2 2634/4885ALDH1A1 2162/4885TP53 389/4885
US-11925658-B2 Phosphoramidate derivatives of 5-fluoro-2′—deoxyuridine for use in the treatment of cancer SLC29A2, SLC29A1, TYMP SMN1; SMN2 2652/4885ALDH1A1 2432/4885TP53 526/4885
US-20250163096-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS MTAP, ADA, ADORA2A SMN1; SMN2 2870/4885ALDH1A1 2246/4885TP53 416/4885
US-20010031745-A1 Antiviral purine derivatives PNP, TYMP, MTAP SMN1; SMN2 1420/4885ALDH1A1 1940/4885TP53 1938/4885
US-20170253629-A1 2' AND/OR 5' AMINO-ACID ESTER PHOSPHORAMIDATE 3'-DEOXY ADENOSINE DERIVATIVES AS ANTI-CANCER COMPOUNDS MTAP, ADA, RNMT SMN1; SMN2 2591/4885ALDH1A1 2194/4885TP53 389/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.