Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 3/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | KIF11 | P52732 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635769 | 0.84 | DRD2 (0.32) | DRD2DRD3PRMT6KDM4EMEN1 | |
| SCHEMBL4635264 | 0.65 | GRM5 (0.41) | GRM5 | |
| SCHEMBL4635772 | 0.65 | GRM5 (0.41) | GRM5 | |
| SCHEMBL4330696 | 0.61 | GRM5 (0.47) | GRM5ALDH1A1HPGD | |
| SCHEMBL18946125 | 0.61 | DRD2 (0.44) | DRD2DRD3GRM5PRMT6KDM4E | |
| SCHEMBL4468086 | 0.60 | DRD2 (0.72) | DRD2DRD3GRM5PRMT6KDM4E | |
| SCHEMBL22685038 | 0.58 | ALDH1A1 (0.59) | PRMT6KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL18946126 | 0.58 | DRD2 (0.50) | DRD2DRD3PRMT6KDM4EMEN1 | |
| SCHEMBL29809089 | 0.58 | DRD2 (0.74) | DRD2DRD3GRM5PRMT6KDM4E | |
| SCHEMBL3537217 | 0.58 | DRD2 (0.74) | DRD2DRD3GRM5PRMT6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | claimed |
| WO-2007023242-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |