Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 19/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635264 | 0.92 | GRM5 (0.41) | GRM5 | |
| SCHEMBL4330696 | 0.81 | GRM5 (0.47) | GRM5 | |
| SCHEMBL4322260 | 0.78 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4329832 | 0.76 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4333916 | 0.73 | ALDH1A1 (0.46) | GRM5 | |
| SCHEMBL4321108 | 0.70 | GRM5 (0.64) | GRM5 | |
| SCHEMBL4340470 | 0.69 | GRM5 (0.60) | GRM5 | |
| SCHEMBL4635769 | 0.65 | DRD2 (0.32) | — | |
| SCHEMBL4635260 | 0.65 | DRD2 (0.32) | GRM5 | |
| SCHEMBL18946125 | 0.65 | DRD2 (0.44) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | claimed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |
| WO-2007023242-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |