Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27714081 | 0.78 | NPSR1 (0.40) | KMT2AMEN1OPRM1OPRD1MAPT | |
| SCHEMBL27827809 | 0.76 | ALDH1A1 (0.41) | KMT2AMEN1OPRM1OPRD1MAPT | |
| SCHEMBL29289914 | 0.75 | IRAK4 (0.37) | IRAK4HSD11B1HRH4 | |
| Hydrochloric Acid SCHEMBL29289750 | 0.74 | IRAK4 (0.36) | IRAK4HSD11B1HRH4 | |
| SCHEMBL27270503 | 0.73 | PARP1 (0.37) | IRAK4NPSR1HSD11B1HRH4 | |
| SCHEMBL20416692 | 0.73 | CCR1 (0.39) | IRAK4NPSR1HSD11B1 | |
| SCHEMBL9298348 | 0.70 | PIM1 (0.42) | IRAK4CNR2P2RX7HSD11B1 | |
| SCHEMBL29860803 | 0.70 | PGK1 (0.41) | KMT2AMEN1CYP1A2IRAK4ADRB1 | |
| SCHEMBL4273303 | 0.70 | PGK1 (0.41) | KMT2AMEN1CYP1A2IRAK4ADRB1 | |
| SCHEMBL5515958 | 0.70 | ADRB1 (0.34) | IRAK4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893609-A1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | Pfizer, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134467-A1 | N-(PYRIDIN-2-YL)-SULFONAMIDE DERIVATIVES | PFIZER INC. (US) | 2006-12-21 | — | — | WO | disclosed |