Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 0.37 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.37 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.37 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.36 |
| ▸ | KCNH2 known ✓ | Q12809 | 3/20 | 0.34 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.33 |
| ▸ | REN known ✓ | P00797 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4635752 | 1.00 | HRH1 (0.38) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4635742 | 1.00 | HRH1 (0.38) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| SCHEMBL4140576 | 0.91 | SLC6A2 (0.42) | SLC6A2SLC6A3HTR1ASLC6A4CHRM2 | |
| SCHEMBL4140578 | 0.91 | SLC6A2 (0.42) | SLC6A2SLC6A3HTR1ASLC6A4CHRM2 | |
| Fumaric Acid SCHEMBL4133212 | 0.86 | HRH1 (0.44) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4140672 | 0.86 | HRH1 (0.44) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4140681 | 0.86 | HRH1 (0.44) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4133224 | 0.86 | HRH1 (0.44) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4133221 | 0.86 | HRH1 (0.44) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 | |
| Fumaric Acid SCHEMBL4138919 | 0.86 | SLC6A2 (0.42) | HRH1SLC6A2SLC6A3HTR1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931653-A2 | THERAPEUTIC PYRROLIDINES | Pfizer Products Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007031828-A2 | THERAPEUTIC PYRROLIDINES | PFIZER PRODUCTS INC. (US) | 2007-03-22 | — | — | WO | disclosed |