SCHEMBL4636283

SCHEMBL4636283

Clc1cc(Cl)c(SSc2cc(Cl)c(Cl)cc2Cl)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
AHR P35869 5/20 0.42
MAPK1 P28482 1/20 0.42
HPGD P15428 2/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
CYP3A4 P08684 1/20 0.37
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36
THRB P10828 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
GUSB P08236 1/20 0.34
DDB1 Q16531 1/20 0.34
CRBN Q96SW2 1/20 0.34
FLT1 P17948 1/20 0.33
CASP1 P29466 1/20 0.32
TP53 P04637 1/20 0.32
FBP1 P09467 1/20 0.31
ERBB2 P04626 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30050744 1.00 MEN1 (0.48) MEN1KMT2AAHRMAPK1HPGD
SCHEMBL11217187 0.88 MEN1 (0.44) MEN1KMT2AAHRMAPK1HPGD
SCHEMBL7263840 0.80 MEN1 (0.61) MEN1KMT2AAHRMAPK1HPGD
SCHEMBL16314636 0.79 MEN1 (0.35) MEN1KMT2AGUSBDDB1CRBN
SCHEMBL10936651 0.78 MEN1 (0.46) MEN1KMT2AAHRMAPK1HPGD
SCHEMBL15072733 0.77 GAA (0.55) MEN1KMT2AMAPK1HPGDTSHR
SCHEMBL30388639 0.77 GAA (0.55) MEN1KMT2AMAPK1HPGDTSHR
SCHEMBL10817138 0.77 CD44 (0.44) MEN1KMT2ACYP3A4FBP1
SCHEMBL15362374 0.75 MEN1 (0.44) MEN1KMT2AAHRMAPK1HPGD
SCHEMBL5031030 0.75 MEN1 (0.44) MEN1KMT2AAHRMAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 303 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6989263-B1 Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2006-01-24 US claimed
US-20030198648-A1 Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA ACHILION PHARMACEUTICALS 2003-10-23 US claimed
WO-2003060098-A2 METHODS FOR IDENTIFYING COMPOUNDS WHICH INHIBIT BINDING OF NUCLEOCAPSID 7 PROTEIN TO HIV-1 RNA ACHILLION PHARMACEUTICALS, INC. (US) 2003-07-24 WO claimed
EP-0782632-B1 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN US GOV HEALTH & HUMAN SERV (US) 2003-04-16 EP claimed
US-6001555-A DISSOCIATING A ZINC FINGER BY CONTACTING THE PROTEIN WITH A DISULFIDE, A MALEIMIDE, AN ALPHA-HALOGENATED KETONE, A HYDRAZIDE, A NITRIC OXIDE OR DERIVATIVES, CUPRIC IONS, FERRIC IONS OR THEIR COMPLEXES; SYNERGISTIC EFFECTS WITH VIRICIDES THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1999-12-14 US claimed
EP-0782632-A1 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the Secretary of the Department of Health and Human Services (US) 1997-07-09 EP claimed
WO-1996009406-A9 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN 1996-05-23 WO claimed
WO-1996009406-A1 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-03-28 WO claimed
JP-11128403-A None JP disclosed
US-12600837-B2 Rubber composition and crosslinked rubber molded product SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2026-04-14 US disclosed
EP-4527473-B1 GOLF BALL SUMITOMO RUBBER IND (JP) 2026-03-25 EP disclosed
US-12544628-B2 Golf ball SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2026-02-10 US disclosed
US-20260027422-A1 GOLF BALL SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2026-01-29 US disclosed
US-20250269241-A1 GOLF BALL SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2025-08-28 US disclosed
WO-1996009406-A9 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN 1996-05-23 WO disclosed
WO-1996009406-A1 A METHOD FOR IDENTIFYING AND USING COMPOUNDS THAT INACTIVATE HIV-1 AND OTHER RETROVIRUSES BY ATTACKING HIGHLY CONSERVED ZINC FINGERS IN THE VIRAL NUCLEOCAPSID PROTEIN THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1996-03-28 WO disclosed
US-4754016-A Process for preparing polyamide with organic phosphine/organic disulfide mixture condensing agent ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1988-06-28 US disclosed
EP-0248932-A1 Process for preparing polyamides Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1987-12-16 EP disclosed
EP-0038459-B1 PROCESS FOR THE PREVENTION OF REVERSION DURING THE MANUFACTURE OF RUBBER VULCANISATES BAYER AG (DE) 1985-07-10 EP disclosed
EP-0038459-A1 Process for the prevention of reversion during the manufacture of rubber vulcanisates BAYER AG (DE) 1981-10-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260027422-A1 GOLF BALL KIF5A, KIF5C, SURF4 MEN1 3064/4885KMT2A 4060/4885AHR 2950/4885
US-12544628-B2 Golf ball KIF5A, KIF5C, SURF4 MEN1 3035/4885KMT2A 3362/4885AHR 2645/4885
US-20030198648-A1 Methods for identifying compounds which inhibit binding of nucleocapsid 7 protein to HIV-1 RNA MRPS27, SNRPE, NSUN2 MEN1 4009/4885KMT2A 4492/4885AHR 4789/4885
US-12600837-B2 Rubber composition and crosslinked rubber molded product RER1, RIF1, SHC1 MEN1 2005/4885KMT2A 1804/4885AHR 1921/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.