Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.52 |
| ▸ | TTK | P33981 | 9/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532498 | 0.93 | HTR6 (0.44) | HTR6TTKSLC6A2MAOAMAOB | |
| SCHEMBL3532214 | 0.91 | HTR6 (0.43) | HTR6TTKSLC6A2MAOAMAOB | |
| Hydrochloric Acid SCHEMBL3530580 | 0.90 | HTR6 (0.42) | HTR6TTKMAOAMAOB | |
| SCHEMBL3529918 | 0.85 | TTK (0.39) | HTR6TTKCA2MAOAMAOB | |
| Trifluoroacetic Acid SCHEMBL3535178 | 0.85 | TTK (0.39) | HTR6TTKCA12CA1CA2 | |
| SCHEMBL3535448 | 0.84 | HTR6 (0.45) | HTR6TTKSLC6A2HTR2A | |
| SCHEMBL3531978 | 0.84 | CA2 (0.41) | HTR6TTKSLC6A2CA2MAOA | |
| SCHEMBL3531911 | 0.84 | HTR6 (0.44) | HTR6TTKSLC6A2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL3535087 | 0.83 | HTR6 (0.44) | HTR6TTKSLC6A2HTR2AHTR2C | |
| SCHEMBL3533331 | 0.82 | SIGMAR1 (0.40) | HTR6TTKSLC6A2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |