Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668504 | 0.90 | P4HB (0.40) | POLBP4HBLMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4636937 | 0.89 | L3MBTL1 (0.38) | POLBLMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL4635633 | 0.87 | L3MBTL1 (0.40) | LMNAL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4635997 | 0.87 | L3MBTL1 (0.40) | LMNAL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4636272 | 0.83 | L3MBTL1 (0.38) | LMNAL3MBTL1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4636280 | 0.82 | ALDH1A1 (0.45) | POLBLMNAL3MBTL1MAPTALDH1A1 | |
| SCHEMBL4636980 | 0.79 | TDP1 (0.38) | POLBLMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL4635990 | 0.78 | L3MBTL1 (0.35) | POLBLMNAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL3327098 | 0.78 | L3MBTL1 (0.35) | POLBLMNAL3MBTL1MAPTSMN1; SMN2 | |
| SCHEMBL4636889 | 0.77 | MEN1 (0.35) | POLBLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306109-A1 | Indolizine Derivatives as Ligands of the Crth2 Receptor | ARGENTA DISCOVERY LIMITED (GB) | 2008-12-11 | — | — | US | disclosed |
| EP-1931663-A1 | IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR | Argenta Discovery Limited (GB) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007031747-A1 | IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR | ARGENTA DISCOVERY LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306109-A1 | Indolizine Derivatives as Ligands of the Crth2 Receptor | HRH4, HRH2, HRH3 | POLB 4665/4885P4HB 2235/4885LMNA 4224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.