Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 3/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639087 | 0.86 | EPAS1 (0.44) | EPAS1PTGDR2SMN1; SMN2 | |
| SCHEMBL4637444 | 0.86 | EPAS1 (0.53) | EPAS1PTGS2PTGS1CYP11B1CYP11B2 | |
| SCHEMBL4637490 | 0.82 | EPAS1 (0.43) | EPAS1PTGDR2SMN1; SMN2LMNA | |
| SCHEMBL4726020 | 0.78 | PTGDR2 (0.41) | EPAS1PTGDR2 | |
| SCHEMBL10950526 | 0.78 | EPAS1 (0.52) | EPAS1PTGS2PTGS1CYP11B1CYP11B2 | |
| SCHEMBL4637412 | 0.77 | PTGS2 (0.43) | EPAS1PTGS2PTGS1CYP11B1CYP11B2 | |
| SCHEMBL10883810 | 0.77 | EPAS1 (0.48) | EPAS1PTGS2PTGS1CYP11B1CYP11B2 | |
| SCHEMBL4637496 | 0.76 | PTGDR2 (0.40) | EPAS1PTGS2PTGS1PTGDR2SMN1; SMN2 | |
| SCHEMBL4637399 | 0.75 | EPAS1 (0.47) | EPAS1PTGDR2 | |
| SCHEMBL4638008 | 0.75 | PTGDR2 (0.41) | EPAS1PTGDR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |