Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PNLIP | P16233 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637470 | 0.87 | SCN9A (0.39) | EPAS1SCN9AKMT2A | |
| SCHEMBL4637574 | 0.85 | EPAS1 (0.51) | EPAS1SCN9A | |
| SCHEMBL4638321 | 0.84 | PLA2G7 (0.40) | EPAS1SCN9APPARGHTTMAPT | |
| SCHEMBL4726020 | 0.83 | PTGDR2 (0.41) | EPAS1SCN9APTGDR2MAPTALDH1A1 | |
| SCHEMBL4637503 | 0.82 | EPAS1 (0.49) | EPAS1PTGDR2SMN1; SMN2LMNA | |
| SCHEMBL4639087 | 0.80 | EPAS1 (0.44) | EPAS1PTGDR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL2066535 | 0.76 | PTGDR2 (0.54) | EPAS1PTGDR2 | |
| SCHEMBL4637476 | 0.74 | SCN9A (0.42) | SCN9APTGDR2SMN1; SMN2CYP3A4 | |
| SCHEMBL10975673 | 0.74 | TSHR (0.58) | HTR6HTTMAPTLMNAALDH1A1 | |
| SCHEMBL4637612 | 0.73 | HTT (0.43) | EPAS1SCN9AHTR6HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |