Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2065489 | 0.84 | PTGDR2 (0.41) | KMT2AMEN1EPAS1SCN9APTPN1 | |
| SCHEMBL883916 | 0.82 | MAPT (0.44) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL4766608 | 0.76 | SLC22A12 (0.46) | MAPTPOLBPKMPLA2G7EPAS1 | |
| SCHEMBL27746551 | 0.74 | PTGDR2 (0.42) | MAPTPOLBPKM | |
| SCHEMBL883855 | 0.72 | PTGDR2 (0.43) | KMT2AMEN1PLA2G7SMN1; SMN2 | |
| SCHEMBL885395 | 0.72 | THRB (0.41) | KMT2AMEN1PTPN1NAMPT | |
| SCHEMBL883878 | 0.71 | PTGDR2 (0.44) | KMT2AMEN1PLA2G7NAMPT | |
| SCHEMBL12076163 | 0.71 | CYP3A4 (0.53) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL8798671 | 0.70 | MAPT (0.85) | MAPTPOLBPKMKMT2AMEN1 | |
| SCHEMBL8896523 | 0.70 | MEN1 (0.50) | KMT2AMEN1PTPN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |