Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | PDE1A | P54750 | 1/20 | 0.34 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637496 | 0.83 | PTGDR2 (0.40) | ALDH1A1PTGDR2MAPT | |
| SCHEMBL4639087 | 0.83 | EPAS1 (0.44) | ALDH1A1PTGDR2SOS1 | |
| SCHEMBL2065827 | 0.81 | PTGDR2 (0.45) | KDM4EALDH1A1PTGDR2 | |
| SCHEMBL2066502 | 0.81 | KDM4E (0.42) | KDM4EALDH1A1PTGDR2MAPTTHRB | |
| SCHEMBL4637399 | 0.80 | EPAS1 (0.47) | ALDH1A1PTGDR2SOS1 | |
| SCHEMBL4638008 | 0.80 | PTGDR2 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL4637476 | 0.77 | SCN9A (0.42) | PTGDR2 | |
| SCHEMBL4637590 | 0.72 | PTGDR2 (0.46) | PTGDR2SOS1 | |
| SCHEMBL4637479 | 0.71 | PTGDR2 (0.41) | ALDH1A1PTGDR2MAPTTHRB | |
| SCHEMBL4637503 | 0.71 | EPAS1 (0.49) | PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |