Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.37 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3261118 | 0.84 | ALDH1A1 (0.37) | PHF8KDM2ACYP1A2ALDH1A1 | |
| SCHEMBL3258041 | 0.82 | LMNA (0.34) | LMNACYP1A2 | |
| SCHEMBL3260130 | 0.77 | ALDH1A1 (0.34) | LMNACYP1A2ALDH1A1 | |
| SCHEMBL3259602 | 0.77 | GABRR1 (0.34) | LMNACYP1A2 | |
| SCHEMBL3187408 | 0.76 | — | — | |
| SCHEMBL13678663 | 0.75 | LMNA (0.35) | PHF8KDM2ALMNAALDH1A1 | |
| SCHEMBL3263226 | 0.75 | PHF8 (0.61) | PHF8KDM2ALMNACYP1A2ALDH1A1 | |
| SCHEMBL3258343 | 0.75 | ALDH1A1 (0.33) | LMNACYP1A2ALDH1A1 | |
| SCHEMBL4616663 | 0.75 | ALDH1A1 (0.39) | PHF8KDM2AALDH1A1 | |
| SCHEMBL3260147 | 0.75 | ALDH1A1 (0.33) | LMNACYP1A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937090-B2 | Parakeratosis inhibitor, pore-shrinking agent and external composition for skin | SHISEIDO COMPANY, LTD. (JP) | 2015-01-20 | — | — | US | disclosed |
| US-20120232111-A1 | Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin | SHISEIDO COMPANY, LTD. (JP) | 2012-09-13 | — | — | US | disclosed |
| EP-1880711-A1 | PARAKERATOSIS INHIBITOR, PORE-SHRINKING AGENT AND EXTERNAL COMPOSITION FOR SKIN | Shiseido Company, Limited (JP) | 2008-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232111-A1 | Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin | CUTA, AAAS, NUP160 | PHF8 2425/4885KDM2A 4081/4885LMNA 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.