Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.35 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637783 | 0.93 | TACR1 (0.41) | TACR1ALDH1A1GPBAR1EPAS1MAPT | |
| SCHEMBL4637701 | 0.93 | GPBAR1 (0.38) | IDH1TACR1ALDH1A1GPBAR1EPAS1 | |
| SCHEMBL4637809 | 0.90 | EPAS1 (0.36) | IDH1TACR1ALDH1A1GPBAR1EPAS1 | |
| SCHEMBL4637937 | 0.89 | IDH1 (0.43) | IDH1ALDH1A1GPBAR1EPAS1MAPT | |
| SCHEMBL4637747 | 0.88 | EPAS1 (0.38) | TACR1ALDH1A1GPBAR1EPAS1MAPT | |
| SCHEMBL4637782 | 0.87 | IDH1 (0.42) | IDH1ALDH1A1GPBAR1EPAS1MAPT | |
| SCHEMBL4639007 | 0.86 | GPBAR1 (0.37) | IDH1TACR1ALDH1A1GPBAR1EPAS1 | |
| SCHEMBL4639367 | 0.84 | TACR1 (0.32) | TACR1GPBAR1EPAS1MAPT | |
| SCHEMBL4638834 | 0.84 | TACR1 (0.32) | TACR1GPBAR1EPAS1MAPT | |
| SCHEMBL4638539 | 0.83 | IDH1 (0.40) | IDH1ALDH1A1GPBAR1EPAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |