Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637945 | 0.93 | EPAS1 (0.37) | EPAS1GPBAR1TACR1MAPTHPGD | |
| SCHEMBL4637966 | 0.92 | KMT2A (0.41) | TACR1MAPTHPGDALDH1A1TP53 | |
| SCHEMBL4637783 | 0.91 | TACR1 (0.41) | EPAS1GPBAR1TACR1MAPTHPGD | |
| SCHEMBL4639367 | 0.91 | TACR1 (0.32) | EPAS1GPBAR1TACR1MAPTTP53 | |
| SCHEMBL4638834 | 0.91 | TACR1 (0.32) | EPAS1GPBAR1TACR1MAPTTP53 | |
| SCHEMBL4639459 | 0.91 | TACR1 (0.34) | EPAS1TACR1MAPTTP53 | |
| SCHEMBL4637701 | 0.90 | GPBAR1 (0.38) | EPAS1GPBAR1TACR1MAPTHPGD | |
| SCHEMBL4637842 | 0.88 | TACR1 (0.36) | TACR1MAPTHPGDTSHRALDH1A1 | |
| SCHEMBL4637940 | 0.88 | IDH1 (0.41) | EPAS1GPBAR1TACR1MAPTHPGD | |
| SCHEMBL4707134 | 0.88 | EPAS1 (0.40) | EPAS1GPBAR1TACR1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |