Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637959 | 0.93 | CNR1 (0.34) | GPBAR1TSHRALDH1A1GRM2IDH1 | |
| SCHEMBL4637782 | 0.92 | IDH1 (0.42) | GPBAR1MAPTRECQLEPAS1TSHR | |
| SCHEMBL4638539 | 0.88 | IDH1 (0.40) | GPBAR1MAPTRECQLEPAS1TSHR | |
| SCHEMBL4639476 | 0.87 | GPBAR1 (0.38) | GPBAR1MAPTRECQLTSHRALDH1A1 | |
| SCHEMBL6385074 | 0.86 | GPBAR1 (0.39) | GPBAR1MAPTRECQLEPAS1TSHR | |
| SCHEMBL4637701 | 0.86 | GPBAR1 (0.38) | GPBAR1MAPTRECQLEPAS1TSHR | |
| SCHEMBL4706505 | 0.86 | RORB (0.35) | GPBAR1GRM2IDH1TACR1 | |
| SCHEMBL4639007 | 0.85 | GPBAR1 (0.37) | GPBAR1MAPTRECQLEPAS1TSHR | |
| SCHEMBL4639003 | 0.84 | CNR1 (0.33) | GPBAR1TSHRALDH1A1IDH1CYP19A1 | |
| SCHEMBL4706457 | 0.82 | ALDH1A1 (0.44) | GPBAR1MAPTRECQLEPAS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-7179804-B2 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2007-02-20 | — | — | US | disclosed |
| US-20050239776-A1 | Tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239776-A1 | Tachykinin receptor antagonists | TACR2, TACR1, PROKR1 | GPBAR1 101/4885MAPT 3592/4885RECQL 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.