Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638135 | 1.00 | CYP1A2 (0.39) | CYP1A2CYP2C9EPHX2PPARGKEAP1 | |
| SCHEMBL6418597 | 0.92 | EPHX2 (0.35) | CYP1A2CYP2C9EPHX2PPARGCETP | |
| SCHEMBL6418121 | 0.83 | POLB (0.49) | PPARGKEAP1NFE2L2HSD17B10LPAR1 | |
| SCHEMBL6418683 | 0.80 | SSTR4 (0.39) | EPHX2CETPHSD17B10LPAR1LPAR5 | |
| SCHEMBL7402677 | 0.79 | EPHX2 (0.36) | EPHX2PPARGCETPALDH1A1 | |
| SCHEMBL6423170 | 0.78 | ALDH1A1 (0.37) | CYP1A2CYP2C9EPHX2PPARGKEAP1 | |
| SCHEMBL6420626 | 0.78 | POLB (0.38) | EPHX2CETPHSD17B10ALDH1A1KMT2A | |
| SCHEMBL7450078 | 0.78 | MTNR1A (0.46) | EPHX2CETPLPAR1LPAR5ALDH1A1 | |
| SCHEMBL2803839 | 0.77 | ALDH1A1 (0.39) | CYP1A2CYP2C9KEAP1HSD17B10ALDH1A1 | |
| SCHEMBL7370769 | 0.77 | PTGER4 (0.43) | KEAP1NFE2L2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628949-A4 | PROCESS AND INTERMEDIATES FOR PREPARING BENZAZEPINES | SMITHKLINE BEECHAM CORP (US) | 2008-07-02 | — | — | EP | disclosed |
| US-7368566-B2 | Process and intermediates for preparing benzazepines | SMITHKLINE BEECHAM CORPORATION (US) | 2008-05-06 | — | — | US | disclosed |
| US-20060194786-A1 | Process and intermediates for preparing benzazepines | SMITHKLINE BEECHAM CORPORATION | 2006-08-31 | — | — | US | disclosed |
| EP-1628949-A2 | PROCESS AND INTERMEDIATES FOR PREPARING BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004089890-A2 | PROCESS AND INTERMEDIATES FOR PREPARING BENZAZEPINES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194786-A1 | Process and intermediates for preparing benzazepines | CYP2E1, CYP1B1, CYP3A4 | CYP1A2 4/4885CYP2C9 8/4885EPHX2 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.