Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | FNTA | P49354 | 2/20 | 0.40 |
| ▸ | FNTB | P49356 | 2/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638362 | 0.89 | CTSK (0.43) | CTSLCTSBCTSKCA1CASP1 | |
| SCHEMBL4929374 | 0.81 | CTSL (0.43) | CTSLCTSBCTSKCA1CASP1 | |
| SCHEMBL5285674 | 0.81 | CTSL (0.47) | CTSLCTSBCTSKCA1HDAC1 | |
| Iodide SCHEMBL4927029 | 0.71 | P2RX7 (0.42) | CTSLCTSBCTSK | |
| SCHEMBL5285679 | 0.71 | CTSK (0.46) | CTSLCTSBCTSKCA1HDAC1 | |
| SCHEMBL150314 | 0.69 | CA1 (0.54) | CTSLCTSBCTSKCA1HDAC1 | |
| SCHEMBL4930098 | 0.69 | CTSL (0.47) | CTSLCTSBCTSKCA1FNTA | |
| SCHEMBL13043797 | 0.69 | CA1 (0.62) | CTSLCTSBCTSKCA1FNTA | |
| SCHEMBL9477021 | 0.68 | TSHR (0.51) | CTSLCTSKPREP | |
| SCHEMBL11705092 | 0.68 | FNTA (0.62) | CTSLCTSBCTSKCA1FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951712-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007059952-A2 | 1-BENZAZEPINE-3-SULFONYLAMINO-2-PYRRLORIDONES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-05-31 | — | — | WO | disclosed |