Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 9/20 | 0.35 |
| ▸ | RORC | P51449 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638464 | 0.95 | RORB (0.36) | RORBRORCCDC7GRM2TACR1 | |
| SCHEMBL4639414 | 0.93 | MAPK1 (0.36) | RORBRORCMAPK1CDC7GRM2 | |
| SCHEMBL4637881 | 0.90 | RORB (0.37) | RORBRORCMAPK1CDC7GRM2 | |
| SCHEMBL4638022 | 0.88 | RORB (0.33) | RORBRORCMAPK1CDC7GRM2 | |
| SCHEMBL4638836 | 0.87 | RORB (0.37) | RORBRORCCDC7GRM2TACR1 | |
| SCHEMBL4708167 | 0.86 | RORB (0.36) | RORBRORCCDC7GRM2TACR1 | |
| SCHEMBL4639445 | 0.85 | RORB (0.39) | RORBRORCCDC7GRM2PTGER4 | |
| SCHEMBL4639531 | 0.84 | RORC (0.34) | RORBRORCTACR1 | |
| SCHEMBL4706911 | 0.83 | RORC (0.33) | RORBRORCTACR1 | |
| SCHEMBL4708796 | 0.83 | TACR1 (0.38) | RORBRORCCDC7TACR1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1501809-B1 | TRIAZOLE DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-01-16 | — | — | EP | disclosed |