Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 18/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 11/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214496 | 0.85 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8652780 | 0.81 | PTGS2 (0.50) | PTGS2PTGS1 | |
| SCHEMBL8653126 | 0.81 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL8654697 | 0.78 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL6691867 | 0.76 | HPGDS (0.38) | PTGS2PTGS1 | |
| SCHEMBL7867029 | 0.76 | PIK3CG (0.43) | PTGS2TDP1 | |
| Sulfamide SCHEMBL4639068 | 0.74 | PTGS2 (0.70) | PTGS2PTGS1MEN1KMT2ATDP1 | |
| Sulfamide SCHEMBL4638294 | 0.74 | PTGS2 (0.70) | PTGS2PTGS1 | |
| SCHEMBL8652522 | 0.73 | PTGS2 (0.53) | PTGS2PTGS1 | |
| SCHEMBL8653562 | 0.73 | PTGS2 (0.72) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479385-B1 | Use of cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia | SEARLE LLC (US) | 2008-07-02 | — | — | EP | claimed |