SCHEMBL4639280

SCHEMBL4639280

O=C(O)NCCc1ccccc1Sc1coc2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NQO2 P16083 3/20 0.40
MAOB P27338 3/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
CDK2 P24941 1/20 0.38
MTNR1A P48039 6/20 0.37
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36
CA12 O43570 1/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4234670 0.83 NQO2 (0.47) NQO2MTNR1AMTNR1BLMNA
SCHEMBL4071116 0.82 IFNAR1 (0.43) MAOBCA2LMNARECQLSMN1; SMN2
SCHEMBL4071697 0.77 IFNAR1 (0.42) MAOBCA2LMNARECQLSMN1; SMN2
SCHEMBL4070391 0.76 IFNAR1 (0.41) MAOBCA2LMNARECQLSMN1; SMN2
SCHEMBL4511347 0.75 CYP1A2 (0.38) MAOBCA2LMNA
SCHEMBL4068784 0.73 IFNAR1 (0.60) MAOBCA2LMNARECQLSMN1; SMN2
SCHEMBL14893264 0.72 LMNA (0.49) NQO2MTNR1AMTNR1BLMNA
Hydrochloric Acid SCHEMBL4067559 0.72 IFNAR1 (0.58) MAOBCA2LMNARECQLSMN1; SMN2
SCHEMBL4063256 0.71 GBA1 (0.36) MAOBLMNASMN1; SMN2
SCHEMBL16353827 0.71 MAOB (0.41) NQO2MAOBMTNR1AHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893596-A2 BENZOÝB¨FURANE AND BENZOÝB¨THIOPHENE DERIVATIVES H.Lundbeck A/S (DK) 2008-03-05 EP disclosed
WO-2007023395-A2 BENZO[B]FURANE AND BENZO[B]THIOPHENE DERIVATIVES H. LUNDBECK A/S (US) 2007-03-01 WO disclosed